Scientists believe they have found a way to beat sleeping sickness using a bacterium against the tsetse fly host that spreads the disease to humans.

In the same way that we have friendly bacteria in our intestines, the tsetse fly harbours bacteria in its midgut, muscle and salivary glands.

Experts in Belgium have genetically modified these “good bugs” so they attack the culprit parasite carried by the fly.

But work is needed to hone the process.

The latest findings are published in the open access journal Microbial Cell Factories.

The disease

Sleeping sickness, or human African trypanosomiasis, is a potentially fatal disease that plagues many regions of Africa.

Although the number of people being infected with the disease has been going down thanks to better diagnosis and treatment, there were still more than 7,000 new cases recorded in 2010.

The parasite causing sleeping sickness is transmitted to humans through the bite of the infected tsetse fly.

This causes fever, headaches, aching joints and itching. Then follows the second stage of disease as the parasites cross the blood-brain barrier to infect the central nervous system.

The person then becomes confused, poorly co-ordinated and experiences the sleep disturbances which give the disease its name.

Without treatment, sleeping sickness is fatal.

But current therapies often have unpleasant side-effects.

Alternatives

The drug most commonly used to treat the condition is a derivative of arsenic developed more than 50 years ago. And the treatment can be excruciatingly painful and potentially fatal. Often described by patients as “fire in the veins,” between 5% and 20% of those treated die of complications from the injected drug.

And so scientists are seeking alternatives.

The Belgium team at the Institute of Tropical Medicine in Antwerp have focused on finding a way to destroy the sleeping sickness parasite – trypanosome – that the tsetse fly carries.

They found bacteria called Sodalis glossinidius, which naturally live in the fly and can be used to mount an attack from the inside.

Altering the genes of the bacteria led it to release fragments of antibodies known as nanobodies against the parasite.

With more work, the researchers hope to be able to produce targeted nanobodies which could kill or block the development of trypanosome.

Dr David Horn of the London School of Hygiene and Tropical Medicine said: “This is a neat and promising concept. The goal now will be to develop a deliverable toxin, not necessarily a nanobody, which exhibits anti-trypanosomal activity in the fly.”

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/health-17024714

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Bravo

Kim Richards opened up to Andy Cohen on the “Real Housewives” reunion.

By Lia Haberman, E! Online

Viewers might have enjoyed this season of “Real Housewives of Beverly Hills” but at least one 90210 TV set was turned off.

Kim Richards’ post-rehab interview with Andy Cohen finally aired last night, and the troubled reality star admitted she couldn’t stand seeing herself onscreen.?

(For anyone who missed the real-time headlines or the zillion Bravo promos running on air and online, Kim also admitted she’s an alcoholic.)

“I had so much guilt and shame for my behavior … then I drank to cover the guilt and shame, to make it go away.”

It was a somber farewell to season two, and not just for Kim.

RELATED:?Beverly Hills “Housewives” star Kim Richards’ recovery update: Taking post-rehab “day by day”

Taylor Armstrong details more of her twisted relationship with former husband Russell Armstrong. She claims he bugged her desk, house and car and had her take a polygraph after accusing her of cheating. He also allegedly spied on her and almost drowned her in a friend’s pool after overhearing Taylor discuss their problems.

And while she won’t respond to Andy’s question about her ex being murdered, Taylor does explain why she finally left him — and it has nothing to do with getting kicked out her circle of Bev Hills friends. “I could have lost my eye,” she says of an altercation with Russell.?

“I was living in a very unhealthy environment, and I drug a lot of my friends into (it), and I have a lot of remorse for that.”

MORE: “Real Housewives of Beverly Hills” reunion recap: Slashed tires, the c-word and suspected murder?!

Dana Wilkey gets to explain why she’s such a flashy kiss-up … after showing off her (bleep)-you heels. We’re still wondering exactly who that scribble was directed at.

“I’m two people,” she tells Andy. “My mom was poor and my dad was rich.” She grew up in Methuen, Mass., where her $25,000 shades are half the median household income. And then moved to New York with her dad where she rubbed shoulders with Manhattan’s elite at Nightingale-Bamford prep school.

So maybe her beef is with Lisa Vanderpump. “Your dog wears attire for every event,” sniped Dana. Or Adrienne Maloof, who’s “got a jet and a casino.” Or Brandi Glanville, who she accuses of being a bad guest at game night for poking at Kim and Kyle Richards.

Any which way, it doesn’t look like Dana’s making the ladies’ speed dial list except for Taylor’s.

MORE: “Real Housewives of Beverly Hills” reunion recap: Lisa Vanderpump’s badonkadonk is under attack

Kim also holds a grudge against Brandi and swears prescription medication was all she took on game night.

She admits she owes the hobbled blonde an apology. “The difference is I owe her one for moving her crutches and she owes me one for basically hurting all the people I love…. One daughter just cried and another one told me you don’t know how hard it is to walk down the street.”?

But since she’s gotten sober, Kim says her kids have come back around, visiting or texting her every night. And while it’s also repaired her relationship with Kyle, sobriety hasn’t reunited her with boyfriend Ken. Kim’s now living in a hotel and hasn’t seen him since rehab.?

MORE:?Wait, what? Which “Real Housewives” star says she hooked up with Gerard Butler??

As for Mauricio Umansky,?his relationship with sister-in-law Kim is still in limbo since no formal apology has been offered. And that’s not all the?”Housewives” hottie is waiting for. Apparently, he hasn’t received one naked fan photo this year.

That might change after tonight’s topless montage that includes a quick flash of Mauricio’s backside as he’s gets ready for a massage.

PHOTOS: Before they were “Housewives”

Ken Todd also believes he’s fairly attractive to women — especially Brandi. “They want me.?And that’s why I wouldn’t take my shirt off in case she attacked me.”

As for?Paul Nassif … well, surgical consultations are bound to increase for Adrienne’s sweet but slightly chubby hubby.

MORE:?Five things to know about the “Real Housewives of Orange County” season seven!

So, was tonight’s interview with Kim enough or would you have liked to hear more about her recovery? Are you feeling differently about Dana after hearing about her humble beginnings? And are there any viewers out there hot for anyone but Mauricio? Share your thoughts on our Facebook page.

Related content:

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Source: http://theclicker.today.msnbc.msn.com/_news/2012/02/14/10404817-beverly-hills-housewives-confess-to-real-problems-with-alcoholism-spousal-paranoia

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Syrian rebels have repelled a push by government tanks into a central town held by forces fighting President Bashar Assad’s regime in an 11-month conflict that looks increasingly like a civil war.

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The military pressed its offensive Monday on Rastan, a day after the regime rejected Arab League calls for the U.N. to create a peacekeeping force in Syria and for an end to the violent crackdown on dissent. Damascus called the League initiative “a flagrant interference in (Syria’s) internal affairs and an infringement upon national sovereignty.”

With diplomatic efforts bogged down, the conflict is taking on the dimensions of a civil war, with army defectors clashing almost daily with soldiers.

The rebels have taken control of small swathes of territory in central Homs province, where Rastan is located, and the northwestern province of Idlib, which borders Turkey.

The Britain-based activist group Syrian Observatory for Human Rights said at least three government soldiers were killed in the attempt to storm Rastan, which has been held by the rebels since late January.

“Troops maneuvered by moving on the northern edge of town, then other forces attacked from the south,” said Rami Abdul-Rahman, who heads the Observatory. He said hundreds of army defectors were in control of Rastan.

Rastan, home to some 50,000 people, was one of the first areas in Syria where people took up arms to fight the regime.

The uprising began last March as mostly peaceful protests against Assad’s authoritarian rule, but has become more militarized in the face of the brutal military crackdown.

‘Widespread destruction’
The U.N. human rights chief, Navi Pillay, told the General Assembly on Monday that more than 5,400 people were killed last year alone, and the number of dead and injured continues to rise daily.

She said tens of thousands of people, including children, have been arrested, more than 18,000 reportedly are still arbitrarily detained and thousands more are reported missing.

UN rights chief: Syria crimes against humanity must not go unpunished

In addition, 25,000 people are estimated to have sought refuge in neighboring countries and more than 70,000 are internally displaced.

“The breadth and patterns of attacks by military and security forces on civilians, and the widespread destruction of homes, hospitals, schools and other civilian infrastructure indicate approval or complicity by authorities at the highest level,” Pillay said.

Video: Syrian FM denies using heavy weapons (on this page)

Rastan was taken by defectors twice in the past only to be retaken by Syrian troops. Calls to residents did not go through on Monday and the telephone lines appeared to be cut, as they usually are during military operations.

The Observatory, which has activists around Syria, said government forces also bombed the rebel-held Homs neighborhood of Baba Amr, which has been under siege for more than a week. It reported clashes in the village of Busra al-Harir in the southern province of Daraa between troops and army defectors.

NYT: For Iraqis, aid to rebels in Syria repays a debt

In the central city of Hama, a sniper shot dead a civilian, the group said. In Idlib, the Observatory said 45 vehicles, including tanks, arrived in the town of Jisr al-Shughour.

Assad’s bloody crackdown on the opposition has left Syria almost completely isolated internationally, except for one key ally ? Russia. China and Russia outraged the U.S. and many Arab countries earlier this month when they delivered a double veto to block a U.N. Security resolution calling on Assad to leave power.

Arab League wants UN peacekeepers in Syria

The 22-nation Arab League has been at the forefront of regional efforts to end the crisis. The group put forward a plan that Assad agreed to in December, then sent in monitors to check whether he was complying. When it became clear the regime was flouting the terms of the agreement and the killings were continuing, the League pulled out the observers last month.

On Sunday, the League called for the Security Council to create a joint Arab-U.N. peacekeeping force for Syria and urged Arab states to sever all diplomatic contact with Damascus.

China tries to limit veto damage
China’s foreign ministry said Tuesday that a Chinese envoy, Li Huaxin, had met the head of the Arab League, Secretary-General Nabil Elaraby, to discuss Syria, as Beijing seeks to limit the diplomatic damage from its veto of the U.N. resolution.

The foreign ministry said its Li had an “extremely frank and useful” exchange with Elaraby.

Video: Activist offers insight on Syrian protests, violence (on this page)

China has insisted its veto did not amount to supporting Assad and was only taken to try and prevent the situation worsening.

But Elaraby has previously said that the veto had cost China and Russia diplomatic credit in the Arab world, and Saudi Arabia’s King Abdullah called the veto an “unfavorable” move.

In Libya, protesters hurled rocks at the Chinese embassy.

“China and Arab countries have a very traditional friendship and cooperative relationship, and maintain close communication and coordination on political affairs,” Li said, according to the Foreign Ministry statement on its website.

“Given the constantly escalating Syrian situation, the purpose of this visit to Cairo was to explain China’s position and policies to the Arab League and Arab countries, and listen to their opinions,” Li said.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/46378492/ns/world_news-asia_pacific/

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AMMAN/BEIRUT (Reuters) ? Syrian forces bombarded districts of Homs and attacked other cities on Monday after Arab states pledged support for the opposition battling President Bashar al-Assad and called for international peacekeepers to be sent to the country.

Tank fire was concentrated on two Sunni Muslim neighborhoods that have been at the forefront of an 11-month-old uprising against Assad, activists said.

“Mortar rounds and bombardment from BTRs (infantry fighting vehicles) are heavily hitting Baba Amro. We do not have numbers for any casualties because there is no communication with the district,” activist Mohammad al-Hassan told Reuters from Homs.

Activists said 23 people were killed on Sunday, adding to a toll of more than 300 since the assault on Homs began on February 3.

The renewed barrages served as an emphatic response to Arab League moves to boost the opposition campaign against Assad, who is resisting calls to step down after 11 years of authoritarian rule.

Meeting in Cairo on Sunday, Arab League ministers proposed a joint United Nations-Arab peacekeeping force for Syria and pledged to provide political and material aid to the opposition.

However, the plan faces all kinds of obstacles. World powers are divided over how to resolve the crisis and Russia and China, who vetoed a U.N. Security Council resolution on Syria on February 4. are unlikely to welcome foreign intervention.

In Moscow, Foreign Minister Sergei Lavrov said Russia was studying the Arab proposal for a peacekeeping mission but wanted more details. He said violence should end before any such mission takes place and international pressure should focus on the Syrian opposition as well as the government.

“In other words, it is necessary to agree to something like a ceasefire but the tragedy is that the armed groups that are confronting the forces of the regime are not subordinate to anyone and are not under control,” Lavrov said.

China’s Foreign Ministry on Monday backed what it termed the Arab League’s “mediation” but offered no clear sign of support for its call for peacekeepers.

“Relevant moves by the United Nations should be conducive towards lessening tension in Syria, pushing political dialogue and resolving differences, as well as maintaining peace and stability in the Middle East, rather than complicating things,” ministry spokesman Liu Weimin told a regular news briefing.

Russia and China were both heavily criticized by the West for blocking the draft U.N. resolution that backed an Arab League call on Assad to step down.

But the United States and European powers are reluctant to get dragged in militarily, fearing this would be more risky and complicated – given Syria’s position along crisscrossing fault lines of Middle East conflict — than the NATO-led air support that helped Libyan rebels oust Muammar Gaddafi last year.

British Foreign Secretary William Hague said on Monday any peacekeeping troops in Syria should come from non-Western countries. “I don’t see the way forward in Syria as being Western boots on the ground in any form, including in any peacekeeping form,” he told reporters in South Africa.

“Of course, if such a concept can be made viable, we will be supporting it in all the usual ways,” said Hague.

The fragmented nature of the opposition to Assad, who is from the Alawite minority in the mostly Sunni Muslim country, is also a problem for those keen on political change in Syria.

The redoubled Arab League effort also highlighted regional rivalries. Its moves have been driven by Saudi Arabia and other Sunni-ruled Gulf monarchies who have long resented Assad’s close ties to Shi’ite regional rival Iran.

Syria, which says it is fighting an insurgency by foreign-backed militants, called the League’s resolution “a flagrant departure from the group’s charter and a hostile act that targets Syria’s security and stability.”

At the United Nations, U.N. Secretary-General Ban Ki-moon’s spokesman said he supported the League’s efforts to stop the violence and seek a peaceful resolution to the crisis.

The Syrian uprising, in which more than 5,000 people have been killed, has become one of the bloodiest of the Arab Spring revolts sweeping the region since the end of 2010.

Analysts say that while Syria is slipping towards a civil war whose sectarian dimensions could inflame the wider region, Assad’s downfall is far from imminent. The unrelenting assaults on opposition strongholds show his determination to crush his foes and resist reforms other than on his own terms, they say.

OVERNIGHT SHELLING

In Homs, government troops concentrated their fire on Baba Amro in the south and al-Waer in the west, which borders the Military College, a main assembly point for tanks and government troops, opposition campaigners said.

Activist Hassan said al-Waer, scene of large pro-democracy demonstrations for months, had come under attack in the last several days from pro-Assad militia known as shabbiha.

“We heard that the Free Syrian Army has started responding by attacking roadblocks being manned by shabbiha. Communications with al-Waer have been cut off and the sound of shelling can be now heard,” Hassan said.

The Free Syrian Army, led by military defectors, has taken the central role in armed opposition to Assad’s government. Accounts on the ground are difficult to verify because Syria restricts access by journalists.

On Sunday amour-backed troops raided the al-Inshaat district of Homs. Tanks ran over civilian cars and troops ransacked houses and burned furniture in the streets as collective punishment, the Coalition of Free Homs said.

A Syrian Red Crescent aid convoy had reached Homs and volunteers were distributing food, medical supplies, and blankets to thousands of people affected by the violence, the International Committee of the Red Cross said.

“The population, particularly the wounded and sick, are bearing the brunt of the violence,” the ICRC chief in Damascus, Marianne Gasser, said.

A YouTube video showed a doctor in al-Bayada district with the bodies of three men on the floor, the body of a woman on a table and an injured man on a bed, with no signs of any medical equipment except for an oxygen bottle.

“We do not have any medicine, equipment or staff. The hospital is this four-meter (yard) by four-meter room,” the doctor said.

The Syrian Observatory for Human Rights said shelling had also started up again on the city of Rastan in Homs province.

Government forces had made failed attempts to storm Rastan at dawn from its southern entrance. Rebels destroyed an armored vehicle and killed three soldiers, the Observatory said.

In the city of Hama, 50 km (28 miles) north of Homs, government forces backed by tanks and armored vehicles killed at least one man when they raided neighborhoods on Sunday near the countryside where the Free Syrian Army has been active.

“It is the third day of such incursions. They fire heavy machineguns and anti-aircraft guns at random, then they go in and raid houses and arrest dozens of people,” activist Fady al-Jaber said from Hama.

The official Syrian news agency said a “terrorist group” had abducted an army colonel in the Qarabees neighborhood of Homs, without giving a date. It said security forces have confiscated weapons and explosives while chasing militants in Hama.

(Additional reporting by Wendell Roelf in Cape Town, Ben Blanchard in Beijing and Steve Gutterman in Moscow; Writing by Angus MacSwan in Beirut; Editing by Mark Heinrich)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120213/wl_nm/us_syria

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Choosing to embark on home improvement jobs can make completely perception. Trying to perform the work on your home enhancement can be extremely hard for some people. In order to improve the value of your property or just help it become far more livable here are a few excellent suggestions.

Exercising in hot weather conditions can be an great way to overlook how much time you?ve been functioning and never drink sufficient water. Monitor efforts and recall you need to keep your body hydrated. Take a moment far from your function and also have a handful of sips water. While you are doing that, take time to enjoy whatever you have done. It might be a concept to change the security security alarm off whenever your realtor is demonstrating the home. In the event the community is dangerous, and you are not any longer residing at the household, an alarm system may be required.

Be sure you hold the suitable products required for your basic safety since you work with a undertaking such as kitchen remodeling San Diego that calls for this sort of points. You always need to procure a harness for the back if you are lifting weighty issues, in addition to a helmet to protect you dropping objects. To obtain stable enter which home changes can raise the value of your property the most, inquire your real estate representative. They have a comprehensive familiarity with all the interests of property customers and the way additions and advancements alter a house?s worth.

Cleaning your rugs persistently really helps make your household show up and sense cleaner. Don?t just vacuum high-traffic regions clean them by using a carpeting shampooing gadget. This will engender an atmosphere of freshness and cleanliness all through your house. Interested in carrying out a tiny updating? Prior to devote any cash, browse around your own home. Make use of the artwork you have shown to give you motivation for brand new projects. Buy photo support frames that compliment the decoration in your home. The weather from your location needs to have an effect about the home remodeling projects you decide to undertake. By way of example, a house in California would warrant a main air cooling technique during a fireplace. Furthermore, a house in the cooler condition may not make use of a swimming pool as much as a house inside a warmer weather conditions.

Accomplishing a house improvement task will not should be overwhelming. Whether you are doing issues by yourself or employing a expert, by using these ideas you?re probably going to be prepared to finish your own home assignments very quickly.

You can read more San Diego Kitchen and Kitchen Remodel San Diego on J.C. Fuentes blog

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Source: http://homeimprovement24.com/great-ideas-and-tips-about-home-renovations/

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We all know that there are so many kinds of best registry cleaners out there nowadays. However, there are simply few options or alternatives that we can consider because the best registry cleaner. This is because like when we are buying any kind of products, we are considering various considerations such as our preference and taste or even criteria. This article will be revealing with you some of the most popular registry cleaners that are regarded as the most effective (not in particular order).

First of all, the top choice of many people for the best registry cleaner is the Registry Booster. This is because as outlined by various surveys and reviews, this specific plan did the best among the remaining portion of the best registry cleaners in relation to speeding up your computers or units. This conclusion was made upon comparing it with the other top and popular registry boosters you can find. However, with its very high position from reviewers, it is expected to be very expensive, which is the bad side of it.

Secondly, another choice from your best registry cleaners that you could want to try is the PC-Matic. In most reviews, it is in reality ranked as the third finest. However, if you are looking for the best registry cleaner with multiple purposes, this can indeed be the best solution. I?ve said this because it is really not a registry cleaner. Instead, it is actually a total optimization software for your personal computer. Hence, exactly what it does is actually more than what you can expect from an ordinary registry cleaner.

Third, if you are looking for some user-friendly registry products, then I think the RegCure is probably the best registry cleaners, or else the best registry cleaner. It is actually regarded as a top choice since it offers interfaces that are made from all kinds of users. Hence, you do not have to become techie person in order to work it at all. Nevertheless, it was still on the fourth spot when it comes to its overall ranking. This is because some still perform greater when it comes fixing some computer registry errors.

Lastly, another popular choice is the Registry Mechanic. Its overall ranking is actually at the second location among the best registry cleaners. Nevertheless, it is not far from the top and total best registry cleaner when it comes to performance. Effectively in fact, it has so many related features with the Registry Booster.

Find more information on the Best registry cleaner by browsing 5bestregistrycleaners.com, or visiting the top resource site for a Slow computer.

Move over, coffee and Red Bull. A Harvard professor thinks the next big thing will be people inhaling their caffeine from a lipstick-sized tube. Critics say the novel product is not without its risks.

The product, called AeroShot, went on the market late last month in Massachusetts and New York, and is also available in France. A single unit costs $2.99 at convenience, mom-and-pop, liquor and online stores.

Biomedical engineering professor David Edwards said AeroShot is safe and does not contain common additives, like taurine, used to amplify the caffeine effect in common energy drinks. Each grey-and-yellow plastic canister contains 100 milligrams of caffeine powder, about the amount in a large cup of coffee, plus B vitamins.

But Democratic U.S. Sen. Charles Schumer of New York wants the U.S. Food and Drug Administration to review AeroShot, saying he fears it will be used as a club drug so that young people can drink until they drop. Schumer?s national press secretary did not immediately respond to calls for comment.

FDA spokeswoman Siobhan DeLancey declined to comment, saying the agency will respond directly to Schumer on the matter.

Edwards said Schumer?s comments are understandable in the context of developments over the last few years, when students looking for a quick and cheap buzz began consuming caffeine-packed alcoholic drinks they dubbed ?blackout in a can? because of their potency. But he said AeroShot is not targeting anyone under 18 and it safely delivers caffeine into the mouth, just like coffee.

?Even with coffee ? if you look at the reaction in Europe to coffee when it first appeared ? there was quite a bit of hysteria,? he said. ?So anything new, there?s always some knee-jerk reaction that makes us believe ?Well, maybe it?s not safe.??

Once a user shoots a puff of calorie-free AeroShot into his or her mouth, the lemon-lime powder begins dissolving almost instantly. Each single-use container has up to six puffs.

?The act of putting it in your mouth is the act of breathing ? so it?s sort of surprising and often people the first time they take the AeroShot, they laugh ? that it?s kind of a funny way of putting food in your mouth,? said Edwards, who also came up with a breathable chocolate product a few years back.

Dr. Lisa Ganjhu, a gastroenterologist and internal medicine doctor at New York-based St. Luke?s-Roosevelt Hospital, said people need to be aware of how much caffeine they are ingesting.

?You want those 10 cups of coffee, it will probably take you a couple hours to get through all that coffee with all that volume that you are drinking,? Ganjhu said. ?With these inhale caffeine canisters you can get that in 10 of those little canisters ? so you just puff away and you could be getting all of that within the hour.?

Even the product packaging warns people not to consume more than three AeroShots per day.

Northeastern University students who sampled the product recently gave it mixed reviews.

?This tastes really good and I think it rocks,? student Zack Huang said after puffing onto a free sample before rushing to join a group of friends who were walking away from campus.

Still, one student was not happy with the taste, echoing sentiment expressed online by some consumers.

People elsewhere vowed they would never give up their morning coffee.

?I want to brew it, I want to stir it and I want to drink it slowly as I absorb the caffeine,? said longtime coffee fan Mark Alexander.

The makers of AeroShot appear to be aware of that sentiment, declaring that the product isn?t about switching away from coffee, but rather making it easier for people with active lifestyles to get their caffeine fix.

?AeroShot can be used in a variety of settings inconvenient for liquids, such as when you study in the library, board an airplane or get into the car for a long drive,? they say in the section dedicated to frequently asked questions on their website. ?It?s easy to take AeroShot with you when you go biking, skiing, curling, or any other activity that consumes energy.?

AeroShot, manufactured in France and the flagship product of Cambridge-based Breathable Foods Inc., is the product of a conversation that Edwards had with celebrity French chef Thierry Marks over lunch in the summer of 2007.

?We were discussing what interesting culinary art experiments we might do together and I had the idea that we might breathe foods since I?ve done a lot of work over the last 10 or 15 years on medical aerosols,? Edwards said.

The first venture Edwards worked on with Harvard students was the breathable chocolate, called Le Whif. Now he?s preparing to promote a product called Le Whaf, which involves putting food and drinks in futuristic-looking glass bowls and turning them into low-calorie clouds of flavor.

Source: http://www.ghanamma.com/2012/02/getting-caffeine-fix-through-your-nose/

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Why Choose Exotic Car Rentals?

If your wedding is just round the corner, then it is important for you to make all the necessary arrangements for the most important day of your life. One of the important things that you need to take care of is the vehicle that will bring you to the wedding ceremony hall. As it is once in a lifetime opportunity you can make full use of this opportunity and hire a luxury car like a Benz or a Porsche or even a Limousine for your wedding. Your entry into the wedding ceremony hall in a posh luxury car will be highlight of the wedding and this will always remain etched in the minds of your invited guests whenever they think about your marriage. So, if you want to make an impression on your wedding date, then choose the best luxury and exotic cars that are available across many of the leading miami exotic car rental companies in the state of Florida. It is advisable to book your luxury car well in advance in order to avoid last minute glitches. As there are many exotic car rental companies in and around Miami, it is important for you to carefully choose the best company and the following tips will be guideline that will make your task a bit easy.

Guidelines To Follow

It is very vital for you to first find a reputable business concern that specializes in renting luxury cars for special occasions. Only these companies will be able to understand your situation better and provide you luxury car hire wedding packages that will include spacious car for the bride and the groom, decoration of car for the special occasion and so on. So, it is advisable that you choose Miami exotic car rentals companies that understands your unique needs and is ready to take up the entire responsibility of providing you the best car hire package facilities for your wedding. Always choose a luxury car rental company that is close by your home or the marriage hall and also check on the experience of the driver. It is advisable that you check the rates for the car hire package that you have chosen and check if the car that you have chosen for your memorable day is insured or not. It is also important for you to provide all that details you require the car rental company to execute on the special day of your life. It is also important for you to shortlist a minimum of three exotic car rental companies in Miami and opt for the best out of the three companies depending on your budget, your needs, experience of the staff and the company, customer reviews as well as cordial and courteous dealings by the company staff.

Conclusion

As you are entering into one of the most important phases of your life, it is all the more important for you to celebrate the wedding day with great pomp and luxury. It is not common for you to have luxuries in your life every day. Hence, choosing the best miami luxury car rental company for your transportation needs during your wedding will add luxury as well as some spice to your wedding.

Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks at a campaign rally in Loveland, Colo., Tuesday, Feb. 7, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks at a campaign rally in Loveland, Colo., Tuesday, Feb. 7, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Pennsylvania Sen. Rick Santorum speaks in Colorado Springs, Colo., Tuesday, Feb. 7, 2012. (AP Photo/Chris Carlson)

Republican presidential candidate, former House Speaker Newt Gingrich speaks at the Colorado Energy Summit in Golden, Colo., Monday, Feb. 6, 2012. (AP Photo/Chris Carlson)

Republican presidential candidate Rep. Ron Paul, R-Texas, signs a campaign poster during a campaign stop Monday, Feb. 6, 2012, in St. Cloud, Minn. (AP Photo/Charles Rex Arbogast)

ST. CHARLES, Mo. (AP) ? Republican front-runner Mitt Romney battled Rick Santorum and Ron Paul on Tuesday in political caucuses in Minnesota and Colorado, hoping to extend his winning streak in the race for the presidential nomination.

Former House Speaker Newt Gingrich mounted no significant campaign in either state, looking ahead to primaries elsewhere.

Romney prevailed in both Minnesota and Colorado in 2008, the first time he ran for the nomination, but the GOP has become more conservative in both states since then under the influence of tea party activists.

There were 37 Republican National Convention delegates at stake in Minnesota and 33 more in Colorado.

In addition, Missouri held a non-binding primary on Tuesday. The state picks its delegates at caucuses next month.

Santorum, a former Pennsylvania senator, campaigned aggressively in all three states, seeking a breakthrough to revitalize a campaign that has struggled since his narrow first-place finish in the Iowa caucuses a month ago.

Paul, a Texas lawmaker, has yet to win a primary or caucus.

Romney began the day the leader in the delegate chase, with 101 of the 1,144 needed to capture the nomination at the Republican National Convention this summer in Tampa. Gingrich had 32, Santorum 17 and Paul nine.

Taken together, the number of delegates at stake Tuesday was the largest one-day total yet in the Republican race to pick a rival for President Barack Obama. Even so, the campaigning was a pale comparison to the Iowa caucuses or primaries last month in New Hampshire, South Carolina and Florida.

Television advertising was sparse; neither Colorado nor Minnesota hosted a candidates’ debate, and there was relatively little campaigning by the contenders themselves until the past few days.

The same was true in last weekend’s Nevada caucuses, which Romney won on the heels of a Florida primary victory days earlier. The same pattern holds in Maine, where caucuses finish on Saturday.

Not until primaries in Michigan and Arizona on Feb. 28 is the campaign likely to regain the intensity that characterized the first few weeks of the year. Then it roars back to life with a 10-state Super Tuesday on March 6 with 416 convention delegates at stake.

Santorum, in particular, hoped to seize the relative lull to redeem the promise of his Iowa victory.

He campaigned more aggressively this week than any of the other contenders, and he spent the day hopscotching from Colorado to Minnesota to Missouri in hopes of nailing down a victory in one of the states. Touting himself as a true conservative ? a slap at Gingrich ? he sought to undermine Romney’s electability claim at the same time by predicting the former Massachusetts governor would lose to Obama.

Romney responded by assailing Santorum as an advocate of congressional earmarks ? shifting the criticism he had leveled at Gingrich when the Georgian seemed a more imposing threat.

In the hours before the caucuses convened, the front-runner sought to lower expectations.

“Mitt Romney is not going to win every contest,” Rich Beeson, the campaign’s political director, wrote in a memo for public consumption.

“John McCain lost 19 states in 2008, and we expect our opponents will notch a few wins, too,” Beeson wrote. McCain, the Arizona senator, won the Republican nomination four years ago.

In fact, Colorado and Minnesota were among the states that McCain failed to win, and he lost them to Romney.

In the four years since, the GOP has become more conservative in both. That posed a challenge for Romney, who runs as the Republican most likely to defeat Obama and is still trying to establish his credentials among tea party activists suspicious of a one-time moderate who backed abortion rights.

Two years ago in Minnesota, establishment candidates for governor were swept aside in the primary, and tea party-backed insurgents for governor and the Senate in Colorado won the party nominations.

In all three cases, Democrats won in the general election that fall.

Gingrich spent the day campaigning in Ohio, one of the primary states on March 6.

His campaign went into a downward spiral after he won the South Carolina primary in an upset. The former speaker was routed in the Florida primary to Romney, then finished a distant second in Nevada over the weekend.

___

David Espo reported from Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-07-US-GOP-Campaign/id-230d481d484e4e4780bc6654ad49c0ff

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